Ursodeoxycholic acid in chronic hepatitis C
نویسندگان
چکیده
منابع مشابه
A large-scale, multicentre, double-blind trial of ursodeoxycholic acid in patients with chronic hepatitis C.
BACKGROUND Combined pegylated interferon and ribavirin has improved chronic hepatitis C (CH-C) therapy; however, sustained virological response is achieved in only about half of the patients with a 1b genotype infection. We assessed oral ursodeoxycholic acid (UDCA) on serum biomarkers as a possible treatment for interferon non-responders. METHODS CH-C patients with elevated alanine aminotrans...
متن کاملTreatment of autoimmune thrombocytopenia in a case of chronic hepatitis C with ursodeoxycholic acid.
Pegylated interferon (PEG-IFN) alpha and ribavirin therapy has become the standard treatment in chronic hepatitis C virus (HCH)-infected patients. While thrombocytopenia associated with IFN use is frequently observed among these patients, autoimmune thrombocytopenia is one of the rarely observed adverse effects. In the present report, we present a case with chronic HCV infection in which autoim...
متن کاملUrsodeoxycholic acid in chronic liver disease.
The hydrophilic bile acid ursodeoxycholic acid has recently been shown to reduce biochemical markers of both cholestasis and hepatocellular damage in patients with chronic liver diseases. The most compelling evidence available is for chronic cholestatic liver diseases, in particular primary biliary cirrhosis, primary sclerosing cholangitis, and cholestasis associated with cystic fibrosis. The e...
متن کاملLong-term treatment of chronic hepatitis C with ursodeoxycholic acid: influence of HCV genotypes and severity of liver disease.
AIMS/BACKGROUND Current therapy for chronic hepatitis C virus (HCV) infection is based on the administration of interferon alpha (IFN) alone or in combination with other anti-viral agents. However, such therapy is effective in only a minority of selected patients. Long-term ursodeoxycholic acid (UDCA) treatment has been reported to improve liver function and structure especially in cholestatic ...
متن کاملUrsodeoxycholic acid
Ursodeoxycholic acid is an epimer of chenodeoxycholic acid (DB06777). It is a mammalian bile acid found first in the bear and is apparently either a precursor or a product of chenodeoxycholate. Its administration changes the composition of bile and may dissolve gallstones. It is used as a cholagogue and choleretic. [PubChem] Indication: The drug reduces cholesterol absorption and is used to dis...
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ژورنال
عنوان ژورنال: Gut
سال: 2007
ISSN: 0017-5749
DOI: 10.1136/gut.2007.130484